First mentioned in the 14th century as the estate of the Grand Duke of Lithuania. In the early 17th century, the manor was owned by the Radziwiłł family. By 1780, the manor complex had two brick mansions—old and new—with an orangery, and a total of about 40 residential and farm buildings. In 1795, the two Žiežmariai manor estates housed seven residents served by seven servants. In 1841, the manor was acquired by Benediktas Tiškevičius, the Marshal of the Nobility of Kaunas Governorate. By 1850, the Žiežmariai manor comprised 720.62 dessiatines of land, including the lands of Jatkonys, Bartaičiai, and Būbliai villages, as well as a land plot within the town itself.
Between 1857 and 1858, under the design of the renowned architect
of the time, Cezaris Anikinis, the manor house, mill, park, canal, ponds, and reinforced embankments were constructed. By 1923, the Žiežmariai manor was recorded with eight homesteads and 148 residents. Following the land reform, the manor was parceled out in 1925, and a village named Žalvarniai was established on its land, with parcels allocated to manor workers and volunteer creators.
From 1927, the manor center, along with approximately 170 hectares of land, was transferred to the Lithuanian Army Invalids' Union. In 1929, the manor house became the home of the Žiežmariai Winter Agricultural School, followed by a progymnasium in 1944, then a secondary school and teachers' dormitory. Since 1994, it has been privately owned.