The history of the church is quite complex. It was started between 1502 and 1508. Around 1620, the church was taken over by Protestants. During the Russian invasion (1654-1655), the church was destroyed but rebuilt in 1672. Until 1914, it was rebuilt three more times.
From 1896 to 1898, the vicar of the church was Honorary Canon Kazimieras Daukša. He was the first to hold Lithuanian services in the Žiežmariai church. His work of spreading Lithuanian culture was continued in the early 20th century by Vicar Father Stanislovas
Šlamas.
In 1914, the old church was demolished, and construction of a new one began, which was interrupted by World War I. Construction resumed in 1922. Without the towers completed and the interior unfinished, the church was consecrated on December 22, 1924. The bells were still in the old wooden bell tower. In 1929, one church tower was built; the second was never completed. Thus, the church stands with one tower to this day.
Currently, the church is part of the St. James Way (Camino Lituano) that runs through Lithuania.